Transcriptional analysis of prsA and vraTS regulatory system in methicillin resistant Staphylococcus aureus against oxacillin stress

D Bhowmik, BJ Das, M Hazarika, DD Chanda… - Indian Journal of …, 2022 - Elsevier
… both hospital and community-acquired infections. Methicillin … and also requires the two-component
regulators, namely vraS … aureus strain N315 which is null mutant of vraS/vraR showed …

… of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus

H Lee, S Boyle-Vavra, J Ren… - Antimicrobial agents …, 2019 - Am Soc Microbiol
regulator (RR) DNA binding transcriptional activator referred to generically as two-component
regulatory systems (… global regulatory system that is activated by OXA and required for the …

[HTML][HTML] The dimerization interface in VraR is essential for induction of the cell wall stress response in Staphylococcus aureus: a potential druggable target

G Tajbakhsh, D Golemi-Kotra - BMC microbiology, 2019 - Springer
… , which is required for optimum binding to its target promoters. Two-component systems have
… vraRM13A did not lead to a response to oxacillin-induced stress. We had earlier suggested …

[PDF][PDF] The Dimerization Interface in VraR is Essential to Induction of the Cell Wall Stress Response in Staphylococcus aureus: A potential Druggable Target

D Golemi-Kotra, G Tajbakhsh - 2019 - yorkspace.library.yorku.ca
… The VraS/VraR two-component regulatory system required for oxacillin resistance in
community-acquired methicillinresistant Staphylococcus aureus. FEMS Microbiol Lett. 2006;262(2):…

[HTML][HTML] Antimicrobial resistance: two-component regulatory systems and multidrug efflux pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
… the requirement of a phosphorylated response regulator [144]. … evgA up-regulation does not
determine resistance to oxacillin, … both nosocomial and community-acquired infections and is …

[HTML][HTML] VraSR Regulatory System Contributes to the Virulence of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) in a 3D-Skin …

N Barua, Y Yang, L Huang, M Ip - Biomedicines, 2021 - mdpi.com
aureus (SA) expresses a wide range of virulence factors regulated by the Two-component
regulatory systems (… VraS and VraR TCR is required for resistance to cell wall antibiotics, eg, …

Detection of vancomycin nonsusceptible strains in clinical isolates of Staphylococcus aureus in northern Iran

L Asadpour, N Ghazanfari - International Microbiology, 2019 - Springer
… safest cure for methicillin-resistant Staphylococcus aureus. The … a two-component regulator
that is involved in regulating the … response regulator of the enzyme, a two-component VraSR …

[HTML][HTML] Pathway-Centric Computational Approach Identifies Molecular Changes Associated with Antibiotic Resistance in Staphylococcus aureus

LK Harris - 2020 - search.proquest.com
… of oxacillin resistance gene expression datasets using KEGG have found up- regulation of
… (M00792)*, LytS-LytR twocomponent regulatory system (M00492)*, Fatty acid biosynthesis …

β-Lactamase Suppression as a Strategy to Target Methicillin-Resistant Staphylococcus aureus: Proof of Concept

PM Thomas, MA Deming, A Sarkar - ACS omega, 2022 - ACS Publications
… (8) Community-acquired MRSA infections are widespread now … two central pathways controlling
oxacillin resistance: A eukaryotic… A close-up view of the VraSR two-component system. A …

NH125 Sensitizes Staphylococcus aureus to Cell Wall-Targeting Antibiotics through the Inhibition of the VraS Sensor Histidine Kinase

S Bhattarai, L Marsh, K Knight, L Ali… - Microbiology …, 2023 - Am Soc Microbiol
Staphylococcus aureus utilizes the two-component regulatory system VraSR to receive
and … for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and …